Enzogenol® Pine (Pinus Radiata) Bark Extract

Enzogenol® is a standardised pine bark extract from New Zealand radiata pine, rich in antioxidant compounds called OPCs. That makes it of particular interest for women 35+. In element3 Rise (AM Formula), Enzogenol® is included at 60mg to support normal cognitive function and provide antioxidant support.

Enzogenol® Pine (Pinus Radiata) Bark Extract

Technical review: Lucy Yang, MFoodTech (Dist.)Reviewed

[ 01 ] Key Facts

Dose in element3 60mg
Form Enzogenol® — standardised OPC extract from NZ Pinus radiata bark; water-extracted, no solvents
Signs you may need more Declining concentration, brain fog, increased anxiety, slow recovery, persistent low-grade inflammation
Safe range 20–450mg daily. Clinical studies have used doses from 50mg to 480mg with no significant adverse effects. element³ uses 60mg as part of a multi-ingredient formula.

Food sources

  • Grape seeds
  • Cocoa

[ 02 ] Rationale

Why this ingredient is in element3

OPCs (oligomeric proanthocyanidins) are a class of polyphenol compounds with exceptional antioxidant potency, in vitro assays estimate OPC radical-scavenging activity at 20–50 times that of Vitamin C and Vitamin E, though in vivo activity reflects the broader complexity of human metabolism. Enzogenol® concentrates these OPCs from NZ radiata pine bark through a water-only extraction process (no chemical solvents), preserving the full spectrum of proanthocyanidins and related polyphenols in their native state.

Enzogenol®’s cognitive benefits have been the subject of multiple clinical trials conducted in New Zealand. Enzogenol® has been the subject of New Zealand clinical trials looking at memory, processing speed and attention. Research describes a role in supporting cerebral blood flow and antioxidant activity in the brain.

Within the RISE formula, Enzogenol® is element³'s standout New Zealand botanical antioxidant. Its OPCs support cerebrovascular function and provide antioxidant protection that complements the broader formula. Alongside the antioxidant vitamin network (C, E, Selenium) and the MITO-ACTIVE™ ingredients (NMN, PQQ, Trans-Resveratrol), Enzogenol® adds botanicals to contribute to a comprehensive approach to antioxidant support to the RISE formula.

Enzogenol® is exclusively sourced from New Zealand, developed and studied by NZ researchers using NZ-grown pine bark.

[ 03 ] Formulator's Notes

From the formulator

Enzogenol is our New Zealand hero ingredient. It has peer-reviewed clinical trials behind it for heart and blood vessel health, it supports normal brain function, and the research shows it can support better attention and memory, which is exactly where brain fog hits.
Lucy YangLucy Yang · Principal Food Technologist, element³

[ 04 ] At 35+

Relevant at 35+

Cognitive changes are a common part of ageing, and many women notice differences in focus and memory from their mid-30s. Enzogenol® is of interest here for its antioxidant role and its studied effects on cognitive measures.

During perimenopause, shifting oestrogen levels can affect how focus and memory feel day to day. Enzogenol®'s antioxidant compounds are studied in this context as part of overall support.

[ 05 ] Your Questions

Your Questions

What is Enzogenol® NZ Pine Bark and what does it do?
Enzogenol® is a standardised extract of OPCs (oligomeric proanthocyanidins) from New Zealand radiata pine bark. It's a concentrated source of antioxidant OPCs, studied for its role in supporting normal cognitive function.

Enzogenol® vs Pycnogenol® - what is the difference?
Both are pine bark extracts rich in OPCs, but they come from different species. Enzogenol® is extracted from NZ Pinus radiata using water-only extraction, while Pycnogenol® comes from French maritime pine (Pinus pinaster). Both have clinical evidence, but Enzogenol® is NZ-sourced with NZ-conducted clinical trials.

Is Enzogenol® NZ Pine Bark extract safe to take daily?
Yes. Enzogenol® has been studied in multiple clinical trials at doses from 50mg to 480mg daily with no significant adverse effects. The 60mg dose in element3 Rise is well within the researched safe range.

OPC supplement — what are OPCs?
OPCs (oligomeric proanthocyanidins) are a class of polyphenol antioxidants found in pine bark, grape seeds, and cocoa. They are estimated to be 20–50 times more potent than Vitamin C in certain antioxidant assays and support vascular health, cognitive function, and healthy inflammatory responses.

[ 06 ] The Research

2 studies

The Research

Study Key finding
Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract FormulationPipingas, A., Silberstein, R. B., Vitetta, L., Rooy, C. V., Harris, E. V., Young, J. M., Frampton, C. M., Sali, A., & Nastasi, J. (2008). Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract formulation. Phytotherapy Research, 22(9), 1168–1174. https://doi.org/10.1002/ptr.2388
Five weeks of Enzogenol® supplementation significantly improved spatial working memory and reaction time in middle-aged adults compared with placebo.
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Article Effects of flavonoid extract Enzogenol((R)) with vitamin C on protein oxidation and DNA damage in older human subjectsSenthilmohan, S. T., Zhang, J., & Stanley, R. A. (2003). Effects of flavonoid extract Enzogenol with vitamin C on protein oxidation and DNA damage in older human subjects. Nutrition Research, 23(9), 1199–1210. https://doi.org/10.1016/S0271-5317(03)00126-3
Enzogenol with vitamin C significantly reduced markers of protein and DNA oxidative damage in older adults relative to placebo.
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[ 07 ] In the Protocol

Where Enzogenol® Pine (Pinus Radiata) Bark Extract sits in the element3 Protocol

In element3 Rise (AM Formula), Enzogenol® at 60mg adds NZ-sourced antioxidant OPCs that support normal cognitive function. It complements the antioxidant vitamins (C, E, Selenium) and the MITO-ACTIVE™ ingredients. Taken in the morning, it's part of element3 Rise's daily support for focus.

You can learn more about the full element3 ingredient philosophy at element3.co.nz.

Good to know

This page is for general education only. It is not medical advice and is not a substitute for advice from your doctor, pharmacist or other health professional. Dietary supplements should not replace a balanced diet. Always read the label and use only as directed. If symptoms persist, or you are pregnant, breastfeeding or taking medication, talk to your health professional before use.